Statistical methods in pharmacoepidemiology: advances and challenges*

Advances in Pharmacoepidemiology & Drug Safety

This article was originally published in a journal by OMICS Publishing Group, and the attached copy is provided by OMICS Publishing Group for the author’s benefit and for the benefit of the author’s institution, for commercial/research/educational use including without limitation use in instruction at your institution, sending it to specific colleagues that you know, and providing a copy to you...

Advances and challenges in recombinant protein expression in Escherichia coli

Statistical Challenges with the Advances in Cancer Therapies

Statistical challenges in designing, analyzing and interpreting the data are being encountered with the recent development of new classes of drugs to treat cancer. The existing paradigm of drug development from Phase I to Phase III clinical trials is not optimal. New and innovative trial designs and statistical methods are needed to evaluate the new classes of drugs. In this chapter we present ...

Monoclonal Antibodies as Therapeutic Agents: Advances and Challenges

Despite the major advances in conventional forms of treatment (i.e. surgical techniques, radiotherapy and chemotherapy) and improved survival rates, cancer is still the second leading cause of death in developing countries. One major limitation of cytotoxic drugs and radiation in the treatment of cancer patients is their inability to discriminate between malignant and normal tissues. This in tu...

Recent Advances in Statistical Methods for Genome-Wide Association Studies

How do we distinguish a needle from a string of hay?